English
1-Hydroxybenzotriazole (HOBt)
Phân loại: Coupling
Thương hiệu: Angene
| CAS Number | 2592-95-2 |
| Catalog Number | AG002R22 |
| Chemical Name | 1-Hydroxybenzotriazole |
| EC Number | 219-989-7 |
| IUPAC Name | 1-hydroxybenzotriazole |
| InChI | InChI=1S/C6H5N3O/c10-9-6-4-2-1-3-5(6)7-8-9/h1-4,10H |
| InChI Key | ASOKPJOREAFHNY-UHFFFAOYSA-N |
| Molecular Formula | C6H5N3O |
| SMILES | On1nnc2c1cccc2 |
| UNII | A2T929DMG4 |
| Synonyms |
1-hydroxybenzotriazole, 1-hydroxybenzotriazole, ammonium salt, 1-hydroxybenzotriazole, sodium salt, HOBt, N-hydroxybenzotriazole, 1-Hydroxybenzotriazole, 2592-95-2, HOBt, 1H-1,2,3-Benzotriazol-1-ol, 1H-Benzo[d][1,2,3]triazol-1-ol, 1H-Benzotriazol-1-ol, 1H-Benzotriazole, 1-hydroxy-, N-Hydroxybenzotriazole, Benzazimidol, Benzazimidol hydrate, 1- |
CHI TIẾT :
DESCRIPTION
General description
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
Application
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
- Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
Other Notes
Widely used additive to decrease racemization in the carbodiimide peptide coupling; Racemization-free condensation of peptide fragments
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
H207 - H319 - H412
Precautionary Statements
P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
Hazard Classifications
2 - Aquatic Chronic 3 - Eye Irrit. 2
Supplementary Hazards
EUH044
Storage Class Code
4.1A - Other explosive hazardous materials
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable