1-Hydroxybenzotriazole (HOBt)

Phân loại: Coupling

Thương hiệu: Angene

CAS Number	2592-95-2
Catalog Number	AG002R22
Chemical Name	1-Hydroxybenzotriazole
EC Number	219-989-7
IUPAC Name	1-hydroxybenzotriazole
InChI	InChI=1S/C6H5N3O/c10-9-6-4-2-1-3-5(6)7-8-9/h1-4,10H
InChI Key	ASOKPJOREAFHNY-UHFFFAOYSA-N
Molecular Formula	C6H5N3O
SMILES	On1nnc2c1cccc2
UNII	A2T929DMG4
Synonyms	1-hydroxybenzotriazole, 1-hydroxybenzotriazole, ammonium salt, 1-hydroxybenzotriazole, sodium salt, HOBt, N-hydroxybenzotriazole, 1-Hydroxybenzotriazole, 2592-95-2, HOBt, 1H-1,2,3-Benzotriazol-1-ol, 1H-Benzo[d][1,2,3]triazol-1-ol, 1H-Benzotriazol-1-ol, 1H-Benzotriazole, 1-hydroxy-, N-Hydroxybenzotriazole, Benzazimidol, Benzazimidol hydrate, 1-

: AG002R22

Đặt Mua

CHI TIẾT :

DESCRIPTION

General description

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.

Application

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:

Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.

Other Notes

Widely used additive to decrease racemization in the carbodiimide peptide coupling; Racemization-free condensation of peptide fragments

SAFETY INFORMATION

Pictograms

Signal Word

Danger

Hazard Statements

H207 - H319 - H412

Precautionary Statements

P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501

Hazard Classifications

2 - Aquatic Chronic 3 - Eye Irrit. 2

Supplementary Hazards

EUH044

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

SẢN PHẨM CÙNG LOẠI

DIC, 98% (GC)

N,N'-Diisopropylcarbodiimide